Yes, there most definitely is.
Advil and Motrin are the same medicine. They contain ibuprofen which is an anti-inflammatory medicine. It is one of the NSAID’s. That stands for non-steroidal anti-inflammatory drugs. They interfere with some of the chemicals in our body that lead to inflammation (swelling and pain). They also reduce the ability for platelets to clot our blood. They are very helpful for pain from inflammation from recent or old injury, arthritis pain as well. Other examples include Alleve which is the same as Naprosyn. The active ingredient is naproxen.
Tylenol has neither of these drugs as ingredients. Tylenol is made of pure acetaminophen. This has no anti-inflammatory properties. Acetominophen is an ingredient in several over the counter and prescription medicines (primarily pain relievers). It does help reduce mild to moderate pain (such as those caused by headaches or minor surgeries), and can also lower fevers. Even though these medicines are sold over the counter without prescription, you should heed the warnings on the label. If you have any serious medical conditions or take other prescription medicines, the you should consult your doctor before taking any of these.